Diabetes

Can a mango a day keep diabetes away: A pioneering study shows the benefits of foods with natural sugars versus added sugars

Taylor Thomas — Wed, 24 Sep 2025 17:31:40 +0000

Can a mango a day keep diabetes away: A pioneering study shows the benefits of foods with natural sugars versus added sugars Taylor Thomas Wed, 09/24/2025 - 13:31

If presented with two snacks, one containing seven grams of sugar and another with more than 30 grams of sugar, choosing the healthier option should be a no-brainer, correct? Well, maybe not. Less sugar is not automatically healthier.

Photo by Luhai Feng/pixababy

For the nearly 100 million adults in the United States who are currently living with prediabetes, a tropical fruit that can reduce the risk of diabetes sounds too good to be true. Tropical fruits contain anywhere between 10 to 50 grams of sugar, with mangos on the high end of the spectrum, making them seem a poor snack choice based on that alone. But research by clinical nutrition researcher Raedeh Basiri indicates that mangos, despite having more sugar than many low-sugar snacks, may offer protective factors for adults with prediabetes.

“It is not just the sugar content that matters, but the overall food context that matters,” said Basiri, assistant professor in ��’s Department of Nutrition and Food Studies. This study is the first long-term clinical trial to demonstrate both metabolic and body composition benefits of mangoes in prediabetes.

Simply put, it’s more than the sugar in the food; it’s about the whole food. The sugars naturally found in mangos, and other fruits, are complemented by fiber and other vitamins and nutrients that offer additional health benefits. Food with added sugar, such as breakfast cereals, and even low-sugar snack options, may not have the same nutritional value and can even increase diabetes risk.

“The goal is to encourage people to include whole fruits, like mango, as part of healthy eating behaviors and practical dietary strategies for diabetes prevention,” said Basiri. “Individuals at high risk of diabetes should not only focus on the sugar content of foods, but on how sugars are delivered.”

Basiri and her team split study participants into two groups; one group received a fresh mango daily, while the other group was given a low-sugar granola bar each day. Over six months, researchers measured participants’ blood glucose levels, bodily responses to insulin, and body fat.

At the conclusion of the study, findings revealed that the high-sugar mango (32 grams of sugar) proved more beneficial than a low-sugar granola bar (11 grams of sugar). The group that consumed the daily mango showed improved blood glucose control, enhanced insulin sensitivity, and reduced body fat.

Daily Mango Intake Improves Glycemic and Body Composition Outcomes in Adults with Prediabetes: A Randomized Controlled Study was published in Foods in August 2025.

This study was funded by the National Mango Board. The authors declare no other potential conflicts of interest. The funders had no role in the design of the study, in the collection, analysis, interpretation of data, or the decision to publish results.

About the researcher

Raedeh Basiri is a registered dietitian and an assistant professor in the Department of Nutrition and Food Studies at George Mason’s College of Public Health. Basiri is a clinical nutrition researcher specializing in personalized nutrition therapy and the use of emerging technologies, such as continuous glucose monitoring, to improve outcomes in individuals with prediabetes, diabetes, and metabolic syndrome. Her work combines randomized controlled trials and large-scale data analysis to investigate how whole foods and dietary patterns impact insulin resistance, glycemic control, sleep, and both mental and gut health. Basiri takes a rigorous, interdisciplinary approach and is deeply committed to chronic disease prevention, collaborative research, and mentoring future professionals.

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Nutrition education can benefit individuals who are overweight with diabetic foot ulcers

Mary Cunningham — Fri, 14 Oct 2022 00:44:49 +0000

Nutrition education can benefit individuals who are overweight with diabetic foot ulcers Mary Cunningham Thu, 10/13/2022 - 20:44

In This Story

Raedeh Basiri, PhD, RDN

A new study by Raedeh Basiri, assistant professor in the Department of Nutrition and Food Studies, suggests that dietary recommendations should prioritize proper wound healing for people who are overweight/obese with diabetic foot ulcers.

Raedeh Basiri, assistant professor in the Department of Nutrition and Food Studies,

Nutrition can play an important role in the treatment of chronic wounds; however, it is often overlooked as part of wound care. Diet therapy is not currently part of standard care for diabetic foot ulcers (DFU), though some research has shown that nutrition can support healing. A new study by Raedeh Basiri, assistant professor in the Department of Nutrition and Food Studies, further supports nutrition intervention to improve clinical outcomes.

Basiri’s new study suggests that dietary recommendations should prioritize proper wound healing for individuals who are overweight/obese with DFUs. Proper wound healing can be prioritized by recommending that patients consume adequate energy sources and essential nutrients, according to the study.

“Routine visits with a dietitian are essential for assessing the dietary needs of patients with diabetic foot ulcers and designing individualized nutrition therapy, which can result in effective clinical outcomes,” said Basiri, the principal investigator. “Identifying the adequate dietary intake of macro- and micronutrients in these patients, especially for those who are overweight or obese, is critical for expediting the wound-healing process and can make a substantial difference to medical expenses and quality of life in this population.”

To the researchers’ knowledge, this is the first study that evaluates the effects of nutrition education and supplementation with extra calories, protein, and micronutrients on long-term blood glucose control and body composition in patients who are overweight and obese with DFUs. In addition to standard DFU care, the treatment group was asked to consume more low-fat protein sources, vegetables, and high-fiber carbohydrates, and a lower amount of simple carbohydrates; educated about and given examples of healthier food items; and provided a nutritional supplement to take twice a day.

On average, patients in the treatment group lost less lean body mass (8.4 lb. vs. 10 lb.) and gained less fat (2 lb. vs. 8 lb.) than the control group. Additionally, DFUs healed 12.85 times faster in the treatment group than in the control group, and inflammation significantly decreased in the treatment group. Previous research by Basiri found that nutritional education and supplements reduced inflammation in DFUs. The research team suspects that Basiri’s previous research, along with previous studies reporting that preventing the loss of lean body mass leads to faster healing of chronic wounds, could be why the treatment group healed quicker.

The findings of this study showed that supplementing a patient’s diet with extra energy sources and nutrients had positive effects on body composition and phase angle (an indicator of cellular health) and did not have any significant negative effects on long-term blood glucose control when combined with nutrition education.

Effects of Nutrition Intervention on Blood Glucose, Body Composition, and Phase Angle in Obese and Overweight Patients with Diabetic Foot Ulcers was published in Nutrients in September 2022. Other researchers included Maria T. Spicer and Thomas Ledermann, and Bahram H. Arjmandi from Florida State University.

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Using Personalized Nutrition to Help Prevent Type 2 Diabetes

Mary Cunningham — Tue, 02 Aug 2022 18:46:25 +0000

Using Personalized Nutrition to Help Prevent Type 2 Diabetes Mary Cunningham Tue, 08/02/2022 - 14:46

In This Story

Raedeh Basiri, PhD, RDN

Lawrence J. Cheskin, MD

Lilian de Jonge, PhD

Raedeh Basiri’s new clinical trial seeks to answer whether personalized nutrition intervention can be effective in lowering blood sugar (and thereby help to prevent or delay type 2 diabetes and related cardiovascular diseases) in people with prediabetes.

Assistant Professor in the Department of Nutrition and Food Studies Raedeh Basiri

One in 10 Americans has diabetes and of those who do, 90% have type 2 diabetes. More than 1 in 3 Americans (96 million people) have prediabetes, many of whom don’t know it. Type 2 diabetes is a preventable disease and Assistant Professor in the Department of Nutrition and Food Studies Raedeh Basiri’s new study hopes that personalized nutrition can stop prediabetes from progressing into type 2 diabetes.

“Many people know general health tips, such as eat more vegetables, yet are not following the health guidelines, which can increase the risk of chronic diseases such as obesity, type 2 diabetes, and cardiovascular diseases,” said Basiri, who is a Registered Dietitian Nutritionist. “We understand that there are many factors that influence individual’s food choices – and sometimes those factors are outside their control. I want to study the why behind why people aren’t following health/dietary guidelines that can help prevent/delay these diseases. Is it access to foods? Their culture? The lack of knowledge? This study looks at how can we as dietitians help people put education into practice based on their individual body and personal desire.”

Type 2 diabetes occurs when there is too much sugar in someone’s bloodstream and it impairs the way the body processes insulin, a hormone that helps the body process sugar (glucose) as fuel. High blood sugar levels can lead to disorders including heart disease, kidney disease, blindness, non-healing foot ulcers, and stroke. With the correct diet and lifestyle adjustments, a person’s blood glucose levels can decrease and return to the non-diabetes range, but type 2 diabetes does not have a cure.

Prediabetes, when blood sugar levels are elevated but not yet at diabetes levels, is reversible if the appropriate lifestyle changes are made. A new study from Basiri and colleagues will help determine to what extent personalized nutrition intervention can help lifestyle changes in participants, who are unaware of having prediabetes or have been diagnosed with prediabetes.

The study emphasizes healthy eating and not weight loss or changing routine exercise to determine if only adjusting food intake will decrease blood glucose level, which in the long term could prevent or delay type 2 diabetes. In the study, the treatment and control groups will receive general dietary recommendations, similar to what would be provided to them in clinical settings currently, and be visited by the researchers once a week.

Participants in the treatment group will receive more individualized nutrition education. The goal is to lower participants’ blood sugar levels while meeting their dietary needs with foods they enjoy. Each person has a unique physiology, which makes food affect people differently. For example, if a person is very sensitive to a certain type of carbohydrates and it raises their blood sugar levels, but they love it, the dietitian will work with the participant on portion size and the best time of day for them to eat it. This is personalized nutrition.

The study, “Individualized Nutrition Therapy for Preventing or Delaying Onset of Type-2 Diabetes,” is a clinical trial. It has been approved by Mason’s Institutional Review Board and ClinicalTrials.gov and is funded by Mason's College of Health and Human Services. Nutrition and Food Studies Chair Larry Cheskin and associate professor Lilian de Jonge are co-investigators on the study.

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Nutritional Supplements and Education Decrease Inflammation in Diabetic Patients with Foot Ulcers

Mary Cunningham — Tue, 28 Jun 2022 15:36:04 +0000

Nutritional Supplements and Education Decrease Inflammation in Diabetic Patients with Foot Ulcers Mary Cunningham Tue, 06/28/2022 - 11:36

In This Story

Raedeh Basiri, PhD, RDN

A new study by Assistant Professor of Nutrition and Food Studies Raedeh Basiri shows that nutritional interventions play a pivotal role in treatment and healing.

Nutritional supplementation and education would support faster healing in patients with Diabetic Foot Ulcers.

A diabetic foot ulcer, an open wound on the foot, affects about 25% of diabetes patients, and without proper care, ulcers can lead to amputation. As with all chronic wounds, diabetic foot ulcers are persistently inflamed, which slows the healing process.

A new study by �� Assistant Professor of Nutrition and Food Studies Raedeh Basiri finds that in people with diabetic foot ulcers, nutritional supplements and nutritional education can significantly decrease inflammation and enhance the healing process.

“Currently, nutritional interventions or referral to dietitians are not part of diabetic foot ulcer standard care. Our results show that nutritional interventions play an important role in decreasing inflammation and should be an integral part of treatment, underscoring the importance of an interdisciplinary approach to clinical care,” said Basiri, who is a Registered Dietitian Nutritionist.

Assistant Professor of Nutrition and Food Studies Raedeh Basiri

Participants in the intervention group of the study were educated about improving their dietary intake by increasing their consumption of low-fat/high-bioavailable protein sources, vegetables, and high-fiber carbohydrates, as well as decreasing their intake of refined and simple carbohydrates.

In addition to nutritional education, patients took a nutritional supplement. People with diabetic foot ulcers have a significantly lower intake of micronutrients, especially potent antioxidants, which have shown the potential to alleviate chronic inflammation. The nutritional supplement provided at least 50% of the Food and Nutrition Board’s recommended dietary allowance (RDA) for antioxidants, and the nutrition education supported patients receiving the remaining antioxidant recommendations from their diet.

The study evaluated the effects of nutrition supplementation and education on inflammatory biomarkers in patients with diabetic foot ulcers. After 12 weeks, concentrations of the inflammatory biomarker IL6 decreased significantly in the intervention group, but increased drastically in the control group. Results on other biomarkers were not statistically significant. The sample size was relatively small, so researchers recommend more clinical trials with larger sizes to confirm the results.

To the research team’s knowledge, this is the first randomized controlled trial that uses both nutrition education and supplementation for improving inflammation status in patients with diabetic foot ulcers. “Improving Dietary Intake of Essential Nutrients Can Ameliorate Inflammation in Patients with Diabetic Foot Ulcers” was published in Nutrients in June 2022.

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Kansas City Star: Dean Germaine Buck Louis comments about a study on a diabetes drug linked to birth defects

eander6 — Fri, 08 Apr 2022 13:11:13 +0000

Kansas City Star: Dean Germaine Buck Louis comments about a study on a diabetes drug linked to birth defects eander6 Fri, 04/08/2022 - 09:11

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Common diabetes drug may raise birth defect risk if dad used it recently, study finds.

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Miami Herald: Dean Germaine Buck Louis comments about a study on a diabetes drug linked to birth defects

eander6 — Fri, 08 Apr 2022 13:09:06 +0000

Miami Herald: Dean Germaine Buck Louis comments about a study on a diabetes drug linked to birth defects eander6 Fri, 04/08/2022 - 09:09

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Common diabetes drug may raise birth defect risk if dad used it recently, study finds.

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College of Health and Human Services

Healio: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects

eander6 — Thu, 31 Mar 2022 19:40:03 +0000

Healio: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects eander6 Thu, 03/31/2022 - 15:40

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Paternal metformin use before conception increases risk for birth defects.

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WBAL TV: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects

eander6 — Thu, 31 Mar 2022 19:33:19 +0000

WBAL TV: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects eander6 Thu, 03/31/2022 - 15:33

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Men's use of diabetes drug before conception linked to 40% increase in birth defects, study finds.

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College of Health and Human Services

WHDH-TV7: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects

eander6 — Thu, 31 Mar 2022 19:27:09 +0000

WHDH-TV7: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects eander6 Thu, 03/31/2022 - 15:27

In This Story

Men’s use of diabetes drug just before conception is linked to a 40% increase in birth defects, study finds.

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College of Health and Human Services

CNN: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects.

eander6 — Thu, 31 Mar 2022 19:10:45 +0000

CNN: Dean Germaine Buck Louis comments on a study linking a diabetes drug to birth defects. eander6 Thu, 03/31/2022 - 15:10

In This Story

Men's use of diabetes drug just before conception is linked to a 40% increase in birth defects, study finds.

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College of Health and Human Services

Diabetes

Can a mango a day keep diabetes away: A pioneering study shows the benefits of foods with natural sugars versus added sugars

Related Stories

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Nutrition education can benefit individuals who are overweight with diabetic foot ulcers

In This Story

A new study by Raedeh Basiri, assistant professor in the Department of Nutrition and Food Studies, suggests that dietary recommendations should prioritize proper wound healing for people who are overweight/obese with diabetic foot ulcers.

Topics

Using Personalized Nutrition to Help Prevent Type 2 Diabetes

In This Story

Raedeh Basiri’s new clinical trial seeks to answer whether personalized nutrition intervention can be effective in lowering blood sugar (and thereby help to prevent or delay type 2 diabetes and related cardiovascular diseases) in people with prediabetes.

Topics

Nutritional Supplements and Education Decrease Inflammation in Diabetic Patients with Foot Ulcers

In This Story

A new study by Assistant Professor of Nutrition and Food Studies Raedeh Basiri shows that nutritional interventions play a pivotal role in treatment and healing.

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Kansas City Star: Dean Germaine Buck Louis comments about a study on a diabetes drug linked to birth defects

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